Jackson is back, and now he has a new partner, karate champion Sean, as they must face a deadly terrorist known as "The Cobra", who has infected Sean with a virus. Sean and Jackson have no choice but to fight the Cobra and his bands of ninjas.

CIA agent Sean Davidson and his sidekick Carl are sent into the stronghold of sadistic British ex-soldier Mulgrew to rescue some Delta Force commandoes who have been captured and tortured. When Sean, Carl and pretty doctor Sarah run into some problems, Peace Corps vet Joe Armstrong is lured out of retirement to stop Mulgrew's plan to explode a nuclear device in New York City.

Joe Armstrong, an orphaned drifter will little respect for much other than martial arts, finds himself on an American Army base in The Philippines after a judge gives him a choice of enlistment or prison. On one of his first missions driving a convoy, his platoon is attacked by a group of rebels who try to steal the weapons the platoon is transporting and kidnap Patricia, the base colonel's daughter, who happens to be along for the ride. Joe rescues Patricia and gets her safely back to the base, but everyone else in the platoon is killed, leading his superiors to conclude that Joe is guilty of cowardice, collaboration or simple incompetence. At the same time, the rebel leader vows revenge against the serviceman who disrupted his plans, and sends an army of ninjas to assassinate him and bring back Patricia. If he wants to survive and save the girl, Joe's going to have to draw on every last ounce of his training.